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Concomitant use of benzodiazepiones, including Valium, and opioids may result in profound sedation, respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.
Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-elated mortality compared to use of opioids alone. If a decision is made to prescribe Valium concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. In patients already receiving an opioid analgesic, prescribe a lower initial dose of Valium than indicated in the absence of an opioid and titrate based on clinical response. If an opioid is initiated in a patient already taking Valium, prescribe a lower initial dose of the opioid and titrate based upon clinical response.
How Does Diazepam Work?
Benzodiazepines including diazepam work by increasing certain chemicals in the brain. These chemicals have a calming effect on the brain which can help to reduce anxiety, help your muscles to relax, or make you feel relaxed or drowsy. It can even stop seizure activity. Sometimes diazepam is prescribed as a sleeping aid.
Because diazepam can have lots of different effects, it is prescribed for a range of different medical conditions. These might include anxiety, difficulty falling asleep or as an emergency medication to be given during seizures. Because diazepam can make you sleep heavily, it is advisable not to consume alcohol when taking diazepam. The combined effect of alcohol and diazepam may lead to changes in your breathing and make it more difficult to wake up.
Diazepam Side Effects
As with other medications, taking diazepam comes with a risk of developing side effects. Keep in mind your doctor prescribed you the drug because they believe that the potential benefits to you outweigh the potential risks and side effects. The good news is that most people who take this medication will not develop side effects. Drowsiness, dizziness, unsteadiness, and blurred vision are some of the more common side effects. You should talk to your doctor pharmacist if you develop these side effects.
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